Genomics,Multiomics

Dataset Information

0

Mus musculus


ABSTRACT: Differentiating 3T3-L1 adipocytes, introduced with siRNA against phf21a gene

OTHER RELATED OMICS DATASETS IN: E-GEOD-18600E-GEOD-18599E-GEOD-18598

PROVIDER: PRJNA123793 | ENA |

REPOSITORIES: ENA

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Publications

FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure.

Hino Shinjiro S   Sakamoto Akihisa A   Nagaoka Katsuya K   Anan Kotaro K   Wang Yuqing Y   Mimasu Shinya S   Umehara Takashi T   Yokoyama Shigeyuki S   Kosai Ken-Ichiro K   Nakao Mitsuyoshi M  

Nature communications 20120327


Environmental factors such as nutritional state may act on the epigenome that consequently contributes to the metabolic adaptation of cells and the organisms. The lysine-specific demethylase-1 (LSD1) is a unique nuclear protein that utilizes flavin adenosine dinucleotide (FAD) as a cofactor. Here we show that LSD1 epigenetically regulates energy-expenditure genes in adipocytes depending on the cellular FAD availability. We find that the loss of LSD1 function, either by short interfering RNA or b  ...[more]

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