Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: Effects of Long-term Pioglitazone Treatment on Peripheral and Central Markers of Aging

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA124145 | ENA |

REPOSITORIES: ENA

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Publications


Thiazolidinediones (TZDs) activate peroxisome proliferator-activated receptor gamma (PPARgamma) and are used clinically to help restore peripheral insulin sensitivity in Type 2 diabetes (T2DM). Interestingly, long-term treatment of mouse models of Alzheimer's disease (AD) with TZDs also has been shown to reduce several well-established brain biomarkers of AD including inflammation, oxidative stress and Abeta accumulation. While TZD's actions in AD models help to elucidate the mechanisms underlyi  ...[more]

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