Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Liver transcriptome profiling of liver specific miR-122 knockout and control male mice

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA124787 | ENA |

REPOSITORIES: ENA

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Publications


miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism and promotes hepatitis C virus (HCV) replication. Reduced miR-122 expression in hepatocellular carcinoma (HCC) correlates with metastasis and poor prognosis. Nevertheless, the consequences of sustained loss of function of miR-122 in vivo have not been determined. Here, we demonstrate that deletion of mouse Mir122 resulted in hepatosteatosis, hepatitis, and the development of tumors resembling HCC. These pathol  ...[more]

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