Dataset Information


Mus musculus

ABSTRACT: Gene expression analysis of leukemic samples in C57BL6 mice

ORGANISM(S): Mus musculus  



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The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

Bursen Adelheid A   Schwabe Karen K   Rüster Brigitte B   Henschler Reinhard R   Ruthardt Martin M   Dingermann Theo T   Marschalek Rolf R  

Blood 20100301 17

The chromosomal translocation t(4;11)(q21;q23) is the most frequent genetic aberration of the human MLL gene, resulting in high-risk acute lymphoblastic leukemia (ALL). To elucidate the leukemogenic potential of the fusion proteins MLL.AF4 and AF4.MLL, Lin(-)/Sca1(+) purified cells (LSPCs) were retrovirally transduced with either both fusion genes or with MLL.AF4 or AF4.MLL alone. Recipients of AF4.MLL- or double-transduced LSPCs developed pro-B ALL, B/T biphenotypic acute leukemia, or mixed lin  ...[more]

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