Dataset Information


Rattus norvegicus

ABSTRACT: Vascular Permeability and Apoptosis are Separable Processes in Retinal Ischemia-Reperfusion Injury

ORGANISM(S): Rattus norvegicus  



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Effects of ischemic preconditioning and bevacizumab on apoptosis and vascular permeability following retinal ischemia-reperfusion injury.

Abcouwer Steven F SF   Lin Cheng-mao CM   Wolpert Ellen B EB   Shanmugam Sumathi S   Schaefer Eric W EW   Freeman Willard M WM   Barber Alistair J AJ   Antonetti David A DA  

Investigative ophthalmology & visual science 20100616 11

PURPOSE: Using transient ischemia followed by reperfusion (IR) to model ischemic retinal disease, this study compares the effects of ischemic preconditioning (IPC) and therapies targeting vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF)-α on retinal apoptosis, vascular permeability, and mRNA expression. METHODS: Rats were subjected to 30 or 45 minutes of retinal ischemia followed by reperfusion for up to 48 hours. Neurodegeneration was quantified by caspase-3 (DEVDase) a  ...[more]

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