Genomics

Dataset Information

59


ABSTRACT: Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells

PROVIDER: PRJNA125269 | ENA |

REPOSITORIES: ENA

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Publications

Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.

Stadtfeld Matthias M   Apostolou Effie E   Akutsu Hidenori H   Fukuda Atsushi A   Follett Patricia P   Natesan Sridaran S   Kono Tomohiro T   Shioda Toshi T   Hochedlinger Konrad K  

Nature 20100425 7295


Induced pluripotent stem cells (iPSCs) have been generated by enforced expression of defined sets of transcription factors in somatic cells. It remains controversial whether iPSCs are molecularly and functionally equivalent to blastocyst-derived embryonic stem (ES) cells. By comparing genetically identical mouse ES cells and iPSCs, we show here that their overall messenger RNA and microRNA expression patterns are indistinguishable with the exception of a few transcripts encoded within the imprin  ...[more]

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