Genomics

Dataset Information

59

Caenorhabditis elegans


ABSTRACT: Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents.

ORGANISM(S): Caenorhabditis elegans  

PROVIDER: PRJNA125817 | ENA |

REPOSITORIES: ENA

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Publications

Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents.

Skjeldam Hanne K HK   Kassahun Henok H   Fensgård Oyvind O   SenGupta Tanima T   Babaie Eshrat E   Lindvall Jessica M JM   Arczewska Katarzyna K   Nilsen Hilde H  

DNA repair 20100520 8


The nematode Caenorhabditis elegans has been used extensively to study responses to DNA damage. In contrast, little is known about DNA repair in this organism. C. elegans is unusual in that it encodes few DNA glycosylases and the uracil-DNA glycosylase (UDG) encoded by the ung-1 gene is the only known UDG. C. elegans could therefore become a valuable model organism for studies of the genetic interaction networks involving base excision repair (BER). As a first step towards characterization of BE  ...[more]

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