Dataset Information


Homo sapiens

ABSTRACT: A compendium of myeloma associated chromosomal copy number abnormalities and their prognostic value

ORGANISM(S): Homo sapiens  



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Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma.

Walker Brian A BA   Wardell Christopher P CP   Chiecchio Laura L   Smith Emma M EM   Boyd Kevin D KD   Neri Antonino A   Davies Faith E FE   Ross Fiona M FM   Morgan Gareth J GJ  

Blood 20101013 2

We used genome-wide methylation microarrays to analyze differences in CpG methylation patterns in cells relevant to the pathogenesis of myeloma plasma cells (B cells, normal plasma cells, monoclonal gammopathy of undetermined significance [MGUS], presentation myeloma, and plasma cell leukemia). We show that methylation patterns in these cell types are capable of distinguishing nonmalignant from malignant cells and the main reason for this difference is hypomethylation of the genome at the transi  ...[more]

Publication: 1/3

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