Genomics

Dataset Information

11


ABSTRACT: Differential roles of Sall4 isoforms in ES cell pluripotency

PROVIDER: PRJNA126441 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Differential roles of Sall4 isoforms in embryonic stem cell pluripotency.

Rao Sridhar S   Zhen Shao S   Roumiantsev Sergei S   McDonald Lindsay T LT   Yuan Guo-Cheng GC   Orkin Stuart H SH  

Molecular and cellular biology 20100913 22


Murine embryonic stem (ES) cells are defined by continuous self-renewal and pluripotency. A diverse repertoire of protein isoforms arising from alternative splicing is expressed in ES cells without defined biological roles. Sall4, a transcription factor essential for pluripotency, exists as two isoforms (Sall4a and Sall4b). Both isoforms can form homodimers and a heterodimer with each other, and each can interact with Nanog. By genomewide location analysis, we determined that Sall4a and Sall4b h  ...[more]

Similar Datasets

2010-01-01 | S-EPMC2976381 | BioStudies
2010-09-13 | E-GEOD-21056 | ArrayExpress
| PRJNA129689 | ENA
1000-01-01 | S-EPMC3184628 | BioStudies
2013-01-01 | S-EPMC3576104 | BioStudies
2010-09-13 | GSE21054 | GEO
2008-01-01 | S-EPMC2604985 | BioStudies
2010-01-01 | S-EPMC2874005 | BioStudies
| PRJNA129691 | ENA
2010-09-13 | GSE21055 | GEO