Genomics

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Saccharomyces cerevisiae


ABSTRACT: Chronological Aging of Yeast in the Absence of Caloric Restriction: Cell Immobilization Uncouples Reproduction from Metabolism

ORGANISM(S): Saccharomyces cerevisiae  

PROVIDER: PRJNA126547 | ENA |

REPOSITORIES: ENA

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Publications

Uncoupling reproduction from metabolism extends chronological lifespan in yeast.

Nagarajan Saisubramanian S   Kruckeberg Arthur L AL   Schmidt Karen H KH   Kroll Evgueny E   Hamilton Morgan M   McInnerney Kate K   Summers Ryan R   Taylor Timothy T   Rosenzweig Frank F  

Proceedings of the National Academy of Sciences of the United States of America 20140331 15


Studies of replicative and chronological lifespan in Saccharomyces cerevisiae have advanced understanding of longevity in all eukaryotes. Chronological lifespan in this species is defined as the age-dependent viability of nondividing cells. To date this parameter has only been estimated under calorie restriction, mimicked by starvation. Because postmitotic cells in higher eukaryotes often do not starve, we developed a model yeast system to study cells as they age in the absence of calorie restri  ...[more]

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