Genomics

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Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases


ABSTRACT: Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases

PROVIDER: PRJNA127179 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR052657.fastq.gz Fastqsanger.gz
SRR052658.fastq.gz Fastqsanger.gz
SRR052659.fastq.gz Fastqsanger.gz
SRR052660.fastq.gz Fastqsanger.gz
SRR052661.fastq.gz Fastqsanger.gz
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Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.

Karginov Fedor V FV   Cheloufi Sihem S   Chong Mark M W MM   Stark Alexander A   Smith Andrew D AD   Hannon Gregory J GJ  

Molecular cell 20100601 6


The life span of a mammalian mRNA is determined, in part, by the binding of regulatory proteins and small RNA-guided complexes. The conserved endonuclease activity of Argonaute2 requires extensive complementarity between a small RNA and its target and is not used by animal microRNAs, which pair with their targets imperfectly. Here we investigate the endonucleolytic function of Ago2 and other nucleases by transcriptome-wide profiling of mRNA cleavage products retaining 5' phosphate groups in mous  ...[more]

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