Dataset Information


Homo sapiens

ABSTRACT: Profiling of direct mRNA targets of miR-130a, miR-203 and miR-205 in prostate cancer cell line LNCaP

ORGANISM(S): Homo sapiens  



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MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma.

Boll K K   Reiche K K   Kasack K K   Mörbt N N   Kretzschmar A K AK   Tomm J M JM   Verhaegh G G   Schalken J J   von Bergen M M   Horn F F   Hackermüller J J  

Oncogene 20120305 3

With ∼30 000 deaths annually in the United States, prostate cancer (PCa) is a major oncologic disease. Here we show that the microRNAs miR-130a, miR-203 and miR-205 jointly interfere with the two major oncogenic pathways in prostate carcinoma and are downregulated in cancer tissue. Using transcriptomics we show that the microRNAs repress several gene products known to be overexpressed in this cancer. Argonaute 2 (AGO2) co-immunoprecipitation, reporter assays and western blot analysis demonstrate  ...[more]

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