Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: OTX2 drives medulloblastoma proliferation via direct regulation of cell cycle genes and inhibits differentiation

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA128125 | ENA |

REPOSITORIES: ENA

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Publications

OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells.

Bunt Jens J   Hasselt Nancy E NE   Zwijnenburg Danny A DA   Hamdi Mohamed M   Koster Jan J   Versteeg Rogier R   Kool Marcel M  

International journal of cancer 20111108 2


The transcription factor OTX2 has been implicated as an oncogene in medulloblastoma, which is the most common malignant brain tumor in children. It is highly expressed in most medulloblastomas and amplified in a subset of them. To study the role OTX2 has in medulloblastoma we investigated the downstream pathway of OTX2. We generated D425 medulloblastoma cells in which endogenous OTX2 can be silenced by inducible shRNA. Silencing of OTX2 strongly inhibited cell proliferation and resulted in a neu  ...[more]

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