Genomics

Dataset Information

118

Trypanosoma brucei


ABSTRACT: Spliced leader trapping reveals widespread alternative splicing patterns in the highly dynamic transcriptome of Trypanosoma brucei

ORGANISM(S): Trypanosoma brucei  

PROVIDER: PRJNA128439 | ENA |

REPOSITORIES: ENA

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Publications

Spliced leader trapping reveals widespread alternative splicing patterns in the highly dynamic transcriptome of Trypanosoma brucei.

Nilsson Daniel D   Gunasekera Kapila K   Mani Jan J   Osteras Magne M   Farinelli Laurent L   Baerlocher Loic L   Roditi Isabel I   Ochsenreiter Torsten T  

PLoS pathogens 20100805 8


Trans-splicing of leader sequences onto the 5'ends of mRNAs is a widespread phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we have developed a method to simultaneously map 5'splice sites and analyze the corresponding gene expression profile, that we term spliced leader trapping (SLT). The method can be applied to any organism with a sequenced genome and trans-splicing of a conserved leader sequence. We analyzed the expression profiles and splicing patterns of blo  ...[more]

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