Genomics,Multiomics

Dataset Information

0

Homo sapiens


ABSTRACT: Genome wide expression data from discordant twins (ulcerative colitis, primary mucosal tissue)

OTHER RELATED OMICS DATASETS IN: E-GEOD-22619

PROVIDER: PRJNA128513 | ENA |

REPOSITORIES: ENA

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Publications

Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis.

Lepage Patricia P   Häsler Robert R   Spehlmann Martina E ME   Rehman Ateequr A   Zvirbliene Aida A   Begun Alexander A   Ott Stephan S   Kupcinskas Limas L   Doré Joël J   Raedler Andreas A   Schreiber Stefan S  

Gastroenterology 20110416 1


<h4>Background & aims</h4>Interactions between genetic and environmental factors are believed to be involved in onset and initiation of inflammatory bowel disease. We analyzed the interaction between gastrointestinal mucosal microbiota and host genes in twin pairs discordant for ulcerative colitis (UC) to study the functional interaction between microbiota and mucosal epithelium.<h4>Methods</h4>Biopsy were collected from sigmoid colon of UC patients and their healthy twins (discordant twin pairs  ...[more]

Publication: 1/2

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