Dataset Information


Rattus norvegicus

ABSTRACT: Neurotoxin tetrodotoxin TTX withdrawal induced neuronal activity: RNA Pol II is poised for rapid induction of arc and other neuronal VF-IEGs

ORGANISM(S): Rattus norvegicus  



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Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II.

Saha Ramendra N RN   Wissink Erin M EM   Bailey Emma R ER   Zhao Meilan M   Fargo David C DC   Hwang Ji-Yeon JY   Daigle Kelly R KR   Fenn J Daniel JD   Adelman Karen K   Dudek Serena M SM  

Nature neuroscience 20110529 7

Transcription of immediate early genes (IEGs) in neurons is highly sensitive to neuronal activity, but the mechanism underlying these early transcription events is largely unknown. We found that several IEGs, such as Arc (also known as Arg3.1), are poised for near-instantaneous transcription by the stalling of RNA polymerase II (Pol II) just downstream of the transcription start site in rat neurons. Depletion through RNA interference of negative elongation factor, a mediator of Pol II stalling,  ...[more]

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