Dataset Information


Homo sapiens

ABSTRACT: Gene expression profiles of HCT116 colorectal carcinoma cells treated with HDAC inhibitors

ORGANISM(S): Homo sapiens  



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Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.

Liu Yanxia Y   Salvador Lilibeth A LA   Byeon Seongrim S   Ying Yongcheng Y   Kwan Jason C JC   Law Brian K BK   Hong Jiyong J   Luesch Hendrik H  

The Journal of pharmacology and experimental therapeutics 20100825 2

Histone deacetylases (HDACs) are validated targets for anticancer therapy as attested by the approval of suberoylanilide hydroxamic acid (SAHA) and romidepsin (FK228) for treating cutaneous T cell lymphoma. We recently described the bioassay-guided isolation, structure determination, synthesis, and target identification of largazole, a marine-derived antiproliferative natural product that is a prodrug that releases a potent HDAC inhibitor, largazole thiol. Here, we characterize the anticancer ac  ...[more]

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