Dataset Information


Homo sapiens

ABSTRACT: Modulation of Cystatin A Expression in Human Airway Epithelium Related to Genotype, Smoking COPD and Lung Cancer

ORGANISM(S): Homo sapiens  



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Modulation of cystatin A expression in human airway epithelium related to genotype, smoking, COPD, and lung cancer.

Butler Marcus W MW   Fukui Tomoya T   Salit Jacqueline J   Shaykhiev Renat R   Mezey Jason G JG   Hackett Neil R NR   Crystal Ronald G RG  

Cancer research 20110216 7

The cathepsin inhibitor Cystatin A (CSTA) has antiapoptotic properties linked with neoplastic changes in squamous cell epithelium, where it has been proposed as a diagnostic and prognostic marker of lung cancer. Notably, cystatin A is upregulated in dysplastic epithelium, prompting us to hypothesize that it might be modulated in chronic obstructive pulmonary disease (COPD), a small airway epithelial (SAE) disorder that is a risk factor for non-small cell lung cancer (NSCLC) in a subset of smoker  ...[more]

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