Genomics

Dataset Information

0

Mus musculus


ABSTRACT: CAST x C57 QTLs Effect on Gene Expression for Chromosomes 2, 11, and 17

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA128995 | ENA |

REPOSITORIES: ENA

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Publications

Serious limitations of the QTL/microarray approach for QTL gene discovery.

Verdugo Ricardo A RA   Farber Charles R CR   Warden Craig H CH   Medrano Juan F JF  

BMC biology 20100712


It has been proposed that the use of gene expression microarrays in nonrecombinant parental or congenic strains can accelerate the process of isolating individual genes underlying quantitative trait loci (QTL). However, the effectiveness of this approach has not been assessed.Thirty-seven studies that have implemented the QTL/microarray approach in rodents were reviewed. About 30% of studies showed enrichment for QTL candidates, mostly in comparisons between congenic and background strains. Thre  ...[more]

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