Dataset Information


Homo sapiens

ABSTRACT: Massively Parallel Sequencing Identifies the MicroRNA Transcriptome of Normal and Malignant Human B cells

ORGANISM(S): Homo sapiens  



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Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs.

Jima Dereje D DD   Zhang Jenny J   Jacobs Cassandra C   Richards Kristy L KL   Dunphy Cherie H CH   Choi William W L WW   Au Wing Yan WY   Srivastava Gopesh G   Czader Magdalena B MB   Rizzieri David A DA   Lagoo Anand S AS   Lugar Patricia L PL   Mann Karen P KP   Flowers Christopher R CR   Bernal-Mizrachi Leon L   Naresh Kikkeri N KN   Evens Andrew M AM   Gordon Leo I LI   Luftig Micah M   Friedman Daphne R DR   Weinberg J Brice JB   Thompson Michael A MA   Gill Javed I JI   Liu Qingquan Q   How Tam T   Grubor Vladimir V   Gao Yuan Y   Patel Amee A   Wu Han H   Zhu Jun J   Blobe Gerard C GC   Lipsky Peter E PE   Chadburn Amy A   Dave Sandeep S SS  

Blood 20100823 23

A role for microRNA (miRNA) has been recognized in nearly every biologic system examined thus far. A complete delineation of their role must be preceded by the identification of all miRNAs present in any system. We elucidated the complete small RNA transcriptome of normal and malignant B cells through deep sequencing of 31 normal and malignant human B-cell samples that comprise the spectrum of B-cell differentiation and common malignant phenotypes. We identified the expression of 333 known miRNA  ...[more]

Publication: 1/2

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