Dataset Information


Homo sapiens

ABSTRACT: Genome-wide mapping of HATs and HDACs in human CD4+ T cells

ORGANISM(S): Homo sapiens  



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Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes.

Wang Zhibin Z   Zang Chongzhi C   Cui Kairong K   Schones Dustin E DE   Barski Artem A   Peng Weiqun W   Zhao Keji K  

Cell 20090820 5

Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to control histone acetylation. As acetylation is a histone mark for active transcription, HATs have been associated with active and HDACs with inactive genes. We describe here genome-wide mapping of HATs and HDACs binding on chromatin and find that both are found at active genes with acetylated histones. Our data provide evidence that HATs and HDACs are both targeted to transcribed regions of active genes by ph  ...[more]

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