Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Bone-marrow derived macrophages response to the Whipple's disease agent, Tropheryma whipplei

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA129025 | ENA |

REPOSITORIES: ENA

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Publications

Type I interferon induction is detrimental during infection with the Whipple's disease bacterium, Tropheryma whipplei.

Al Moussawi Khatoun K   Ghigo Eric E   Kalinke Ulrich U   Alexopoulou Lena L   Mege Jean-Louis JL   Desnues Benoit B  

PLoS pathogens 20100115 1


Macrophages are the first line of defense against pathogens. Upon infection macrophages usually produce high levels of proinflammatory mediators. However, macrophages can undergo an alternate polarization leading to a permissive state. In assessing global macrophage responses to the bacterial agent of Whipple's disease, Tropheryma whipplei, we found that T. whipplei induced M2 macrophage polarization which was compatible with bacterial replication. Surprisingly, this M2 polarization of infected  ...[more]

Publication: 1/2

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