Dataset Information


Rattus norvegicus

ABSTRACT: preparative changes in rat intestine and lung for birth

ORGANISM(S): Rattus norvegicus  



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Paraoxonase-3, a putative circulating antioxidant, is systemically up-regulated in late gestation in the fetal rat, sheep, and human.

Belteki Gusztav G   Kempster Sarah L SL   Forhead Alison J AJ   Giussani Dino A DA   Fowden Abigail L AL   Curley Anna A   Charnock-Jones D Stephen DS   Smith Gordon C S GC  

The Journal of clinical endocrinology and metabolism 20100512 8

CONTEXT:Surfactant is a successful therapeutic based on supplementing preterm infants with a substance that would normally have been up-regulated in late gestation. Although prematurity is associated with oxidative stress, no effective antioxidant therapy has yet been identified. OBJECTIVE:Our objective was to identify endogenous antioxidants involved in fetal preparation for birth. DESIGN:We performed transcript profiling of fetal rat lung and intestine at 16 d gestational age (dGA) and 20 dGA  ...[more]

Publication: 1/2

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