Dataset Information


Mus musculus

ABSTRACT: CpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data]

ORGANISM(S): Mus musculus  



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CpG islands recruit a histone H3 lysine 36 demethylase.

Blackledge Neil P NP   Zhou Jin C JC   Tolstorukov Michael Y MY   Farcas Anca M AM   Park Peter J PJ   Klose Robert J RJ  

Molecular cell 20100401 2

In higher eukaryotes, up to 70% of genes have high levels of nonmethylated cytosine/guanine base pairs (CpGs) surrounding promoters and gene regulatory units. These features, called CpG islands, were identified over 20 years ago, but there remains little mechanistic evidence to suggest how these enigmatic elements contribute to promoter function, except that they are refractory to epigenetic silencing by DNA methylation. Here we show that CpG islands directly recruit the H3K36-specific lysine de  ...[more]

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