Dataset Information


Homo sapiens

ABSTRACT: Ribavirin Treated Huh7.5.1 Cells

ORGANISM(S): Homo sapiens  



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Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models.

Thomas Emmanuel E   Feld Jordan J JJ   Li Qisheng Q   Hu Zongyi Z   Fried Michael W MW   Liang T Jake TJ  

Hepatology (Baltimore, Md.) 20101026 1

UNLABELLED:The combination of pegylated interferon (PEG-IFN) and ribavirin is the standard treatment for chronic hepatitis C. Our recent clinical study suggests that ribavirin augments the induction of interferon-stimulated genes (ISGs) in patients treated for hepatitis C virus (HCV) infection. In order to further characterize the mechanisms of action of ribavirin, we examined the effect of ribavirin treatment on ISG induction in cell culture. In addition, the effect of ribavirin on infectious H  ...[more]

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