Genomics,Multiomics

Dataset Information

0

Homo sapiens


ABSTRACT: Expression data from human NHL cell lines treated with agonistic antibodies

OTHER RELATED OMICS DATASETS IN: E-GEOD-23394

PROVIDER: PRJNA131291 | ENA |

REPOSITORIES: ENA

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Publications

Antibodies against CD20 or B-cell receptor induce similar transcription patterns in human lymphoma cell lines.

Franke Andreas A   Niederfellner Gerhard J GJ   Klein Christian C   Burtscher Helmut H  

PloS one 20110218 2


<h4>Background</h4>CD20 is a cell surface protein exclusively expressed on B cells. It is a clinically validated target for Non-Hodgkin's lymphomas (NHL) and autoimmune diseases. The B cell receptor (BCR) plays an important role for development and proliferation of pre-B and B cells. Physical interaction of CD20 with BCR and components of the BCR signaling cascade has been reported but the consequences are not fully understood.<h4>Methodology</h4>In this study we employed antibodies against CD20  ...[more]

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