Genomics,Multiomics

Dataset Information

0

Homo sapiens


ABSTRACT: Transcriptome Signatures of Sezary Cells from Patients and Cultured Hut 78, Hut 102 and Jurkat Cells

OTHER RELATED OMICS DATASETS IN: E-GEOD-24951

PROVIDER: PRJNA131499 | ENA |

REPOSITORIES: ENA

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Publications

Deficiency of SATB1 expression in Sezary cells causes apoptosis resistance by regulating FasL/CD95L transcription.

Wang Yang Y   Su Mingwan M   Zhou Liang L LL   Tu Ping P   Zhang Xuejun X   Jiang Xiaoyan X   Zhou Youwen Y  

Blood 20110126 14


Sézary syndrome (SS) is an aggressive subtype of cutaneous T-cell lymphoma that is characterized by circulating leukemic Sézary cells. The accumulation of these malignant cells has been shown to be the result of the resistance to apoptosis, in particular, activation-induced cell death. However, the mechanism of apoptosis resistance remains unknown. By characterizing the gene transcription profiles of purified CD4(+)CD7(-) Sézary cells from patients with SS and cultured Sézary cells, it was found  ...[more]

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