Dataset Information


Homo sapiens

ABSTRACT: Expression profiles from HEK293 cells by overexpression of TRPM7 channel



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Alteration of the transcriptional profile of human embryonic kidney cells by transient overexpression of mouse TRPM7 channels.

Lee Byoung-Cheol BC   Hong Seong-Eui SE   Lim Hyun-Ho HH   Kim Do Han DH   Park Chul-Seung CS  

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110401 3-4

<h4>Background</h4>TRPM7 is a cation channel containing a functional kinase domain. The functional activity of TRPM7 is essential for cell viability and growth, and its expression is up-regulated in certain pathological conditions, such as ischemia.<h4>Methods</h4>In order to assess the effects of TRPM7 activity on cellular gene expression, inducible HEK293 cell-lines harboring the wild-type mouse TRPM7 and a mutant lacking the kinase domain were established. The wild-type and the non-functional  ...[more]

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