Genomics

Dataset Information

0

Tetrahymena thermophila


ABSTRACT: A growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo

ORGANISM(S): Tetrahymena thermophila  

PROVIDER: PRJNA132107 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR070072.fastq.gz Fastqsanger.gz
SRR070073.fastq.gz Fastqsanger.gz
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Publications

A growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo.

Couvillion Mary T MT   Sachidanandam Ravi R   Collins Kathleen K  

Genes & development 20101124 24


Argonaute/Piwi proteins associate with small RNAs that typically provide sequence specificity for RNP function in gene and genome regulation. Here we show that Twi12, a Tetrahymena Piwi protein essential for growth, is loaded with mature tRNA fragments. The tightly bound ~18- to 22-nucleotide tRNA 3' fragments are biochemically distinct from the tRNA halves produced transiently in response to stress. Notably, the end positions of Twi12-bound tRNA 3' fragments precisely match RNAs detected in tot  ...[more]

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