Genomics

Dataset Information

0

Escherichia coli str. K-12 substr. MG1655


ABSTRACT: Identification of genes induced on nitrate, role of OxyR

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655  

PROVIDER: PRJNA132657 | ENA |

REPOSITORIES: ENA

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Publications

Endogenous protein S-Nitrosylation in E. coli: regulation by OxyR.

Seth Divya D   Hausladen Alfred A   Wang Ya-Juan YJ   Stamler Jonathan S JS  

Science (New York, N.Y.) 20120401 6080


Endogenous S-nitrosylation of proteins, a principal mechanism of cellular signaling in eukaryotes, has not been observed in microbes. We report that protein S-nitrosylation is an obligate concomitant of anaerobic respiration on nitrate in Escherichia coli. Endogenous S-nitrosylation during anaerobic respiration is controlled by the transcription factor OxyR, previously thought to operate only under aerobic conditions. Deletion of OxyR resulted in large increases in protein S-nitrosylation, and S  ...[more]

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