Genomics

Dataset Information

14

Mus musculus


ABSTRACT: Potential mechanisms of endocrine disruptors as revealed by uterine gene profile

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA132659 | ENA |

REPOSITORIES: ENA

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Publications

Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles.

Hewitt Sylvia C SC   Korach Kenneth S KS  

Environmental health perspectives 20100908 1


Interest and concern regarding potentially estrogenic substances have resulted in development of model systems to evaluate mechanisms of such chemicals. Microarray studies have indicated that estradiol (E2)-stimulated uterine responses can be divided into early and late phases. Comparison of E2 uterine transcript profiles and those of other estrogenic chemicals of interest in vivo indicates mechanisms and activities of test compounds.We compared transcript responses and mechanisms of response us  ...[more]

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