Genomics

Dataset Information

0

Danio rerio


ABSTRACT: Expression analysis of transgenic embryos carrying the mitf-BRAFV600E allele in the presence or absence of p53 function

ORGANISM(S): Danio rerio  

PROVIDER: PRJNA132667 | ENA |

REPOSITORIES: ENA

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Publications


Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma. We have used zebrafish embryos to identify the initiating transcriptional events that occur on activation of human BRAF(V600E) (which encodes an amino acid substitution mutant of BRAF) in the neural cres  ...[more]

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