Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: A unique chromatin signature uncovers early developmental enhancers in humans

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA132687 | ENA |

REPOSITORIES: ENA

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Publications

A unique chromatin signature uncovers early developmental enhancers in humans.

Rada-Iglesias Alvaro A   Bajpai Ruchi R   Swigut Tomek T   Brugmann Samantha A SA   Flynn Ryan A RA   Wysocka Joanna J  

Nature 20101215 7333


Cell-fate transitions involve the integration of genomic information encoded by regulatory elements, such as enhancers, with the cellular environment. However, identification of genomic sequences that control human embryonic development represents a formidable challenge. Here we show that in human embryonic stem cells (hESCs), unique chromatin signatures identify two distinct classes of genomic elements, both of which are marked by the presence of chromatin regulators p300 and BRG1, monomethylat  ...[more]

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