Genomics

Dataset Information

118

Genome-wide comparative ChIP-seq data of CTCF and RNA-seq data in Drosophila white prepupa on Illumina Genome Analyzer


ABSTRACT: Genome-wide comparative ChIP-seq data of CTCF and RNA-seq data in Drosophila white prepupa on Illumina Genome Analyzer

PROVIDER: PRJNA132691 | ENA |

REPOSITORIES: ENA

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Publications

Adaptive evolution and the birth of CTCF binding sites in the Drosophila genome.

Ni Xiaochun X   Zhang Yong E YE   Nègre Nicolas N   Chen Sidi S   Long Manyuan M   White Kevin P KP  

PLoS biology 20121106 11


Changes in the physical interaction between cis-regulatory DNA sequences and proteins drive the evolution of gene expression. However, it has proven difficult to accurately quantify evolutionary rates of such binding change or to estimate the relative effects of selection and drift in shaping the binding evolution. Here we examine the genome-wide binding of CTCF in four species of Drosophila separated by between ∼2.5 and 25 million years. CTCF is a highly conserved protein known to be associated  ...[more]

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