Dataset Information


Homo sapiens

ABSTRACT: 183 breast tumors from the Helsinki Univerisity Central Hospital with survival information

ORGANISM(S): Homo sapiens  



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Variants on the promoter region of PTEN affect breast cancer progression and patient survival.

Heikkinen Tuomas T   Greco Dario D   Pelttari Liisa M LM   Tommiska Johanna J   Vahteristo Pia P   Heikkilä Päivi P   Blomqvist Carl C   Aittomäki Kristiina K   Nevanlinna Heli H  

Breast cancer research : BCR 20111215 6

INTRODUCTION: The PTEN gene, a regulator of the phosphatidylinositol-3-kinase (PI3K)/Akt oncogenic pathway, is mutated in various cancers and its expression has been associated with tumor progression in a dose-dependent fashion. We investigated the effect of germline variation in the promoter region of the PTEN gene on clinical characteristics and survival in breast cancer. METHODS: We screened the promoter region of the PTEN gene for germline variation in 330 familial breast cancer cases and fu  ...[more]

Publication: 1/2

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