Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Knockout of the Acyl CoA binding protein (ACBP) in mice - expression profile from the liver of 21 days old ACBP-/- and +/+ mice.

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA132695 | ENA |

REPOSITORIES: ENA

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Publications

Disruption of the acyl-CoA-binding protein gene delays hepatic adaptation to metabolic changes at weaning.

Neess Ditte D   Bloksgaard Maria M   Bek Signe S   Marcher Ann-Britt AB   Elle Ida C IC   Helledie Torben T   Due Marianne M   Pagmantidis Vasileios V   Finsen Bente B   Wilbertz Johannes J   Kruhøffer Mogens M   Færgeman Nils N   Mandrup Susanne S  

The Journal of biological chemistry 20101124 5


The acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor is an intracellular protein that binds C(14)-C(22) acyl-CoA esters and is thought to act as an acyl-CoA transporter. In vitro analyses have indicated that ACBP can transport acyl-CoA esters between different enzymatic systems; however, little is known about the in vivo function in mammalian cells. We have generated mice with targeted disruption of ACBP (ACBP(-/-)). These mice are viable and fertile and develop normally. However, arou  ...[more]

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