Dataset Information


Homo sapiens

ABSTRACT: Secreted Factors from Staphylococcus aureus Biofilm and Planktonic Cultures Differentially Impact Human Keratinocytes in vitro

ORGANISM(S): Homo sapiens  



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Staphylococcus aureus Biofilm and Planktonic cultures differentially impact gene expression, mapk phosphorylation, and cytokine production in human keratinocytes.

Secor Patrick R PR   James Garth A GA   Fleckman Philip P   Olerud John E JE   McInnerney Kate K   Stewart Philip S PS  

BMC Microbiology 20110621

Many chronic diseases, such as non-healing wounds are characterized by prolonged inflammation and respond poorly to conventional treatment. Bacterial biofilms are a major impediment to wound healing. Persistent infection of the skin allows the formation of complex bacterial communities termed biofilm. Bacteria living in biofilms are phenotypically distinct from their planktonic counterparts and are orders of magnitude more resistant to antibiotics, host immune response, and environmental stress.  ...[more]

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