Dataset Information


Homo sapiens

ABSTRACT: IGROV1 gene expression analysis after in vivo locoregional treatment with CpG-ODN

ORGANISM(S): Homo sapiens  



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TLR9 agonists oppositely modulate DNA repair genes in tumor versus immune cells and enhance chemotherapy effects.

Sommariva Michele M   De Cecco Loris L   De Cesare Michelandrea M   Sfondrini Lucia L   Ménard Sylvie S   Melani Cecilia C   Delia Domenico D   Zaffaroni Nadia N   Pratesi Graziella G   Uva Valentina V   Tagliabue Elda E   Balsari Andrea A  

Cancer research 20110830 20

Synthetic oligodeoxynucleotides expressing CpG motifs (CpG-ODN) are a Toll-like receptor 9 (TLR9) agonist that can enhance the antitumor activity of DNA-damaging chemotherapy and radiation therapy in preclinical mouse models. We hypothesized that the success of these combinations is related to the ability of CpG-ODN to modulate genes involved in DNA repair. We conducted an in silico analysis of genes implicated in DNA repair in data sets obtained from murine colon carcinoma cells in mice injecte  ...[more]

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