Dataset Information


Rattus norvegicus

ABSTRACT: Fetal Rat Testis mRNA Expression after 50 mg/kg Dibutyl Phthalate Exposure

ORGANISM(S): Rattus norvegicus  



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Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways.

Johnson Kamin J KJ   McDowell Erin N EN   Viereck Megan P MP   Xia Jessie Q JQ  

Toxicological sciences : an official journal of the Society of Toxicology 20110125 2

Fetal rat phthalate exposure produces a spectrum of male reproductive tract malformations downstream of reduced Leydig cell testosterone production, but the molecular mechanism of phthalate perturbation of Leydig cell function is not well understood. By bioinformatically examining fetal testis expression microarray data sets from susceptible (rat) and resistant (mouse) species after dibutyl phthalate (DBP) exposure, we identified decreased expression of several metabolic pathways in both species  ...[more]

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