Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Asymmetric self-renewal associated (ASRA) genes

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA134861 | ENA |

REPOSITORIES: ENA

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Publications

A resource for discovering specific and universal biomarkers for distributed stem cells.

Noh Minsoo M   Smith Janet L JL   Huh Yang Hoon YH   Sherley James L JL  

PloS one 20110719 7


Specific and universal biomarkers for distributed stem cells (DSCs) have been elusive. A major barrier to discovery of such ideal DSC biomarkers is difficulty in obtaining DSCs in sufficient quantity and purity. To solve this problem, we used cell lines genetically engineered for conditional asymmetric self-renewal, the defining DSC property. In gene microarray analyses, we identified 85 genes whose expression is tightly asymmetric self-renewal associated (ASRA). The ASRA gene signature prescrib  ...[more]

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