Dataset Information


Macaca mulatta

ABSTRACT: Microarray analysis of the transcriptome in the primate corpus luteum during chorionic gonadotropin administration simulating early pregnancy.

ORGANISM(S): Macaca mulatta  



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Microarray analysis of the primate luteal transcriptome during chorionic gonadotrophin administration simulating early pregnancy.

Bishop C V CV   Satterwhite S S   Xu L L   Hennebold J D JD   Stouffer R L RL  

Molecular human reproduction 20111109 4

To explore chorionic gonadotrophin (CG)-regulated gene expression in the primate corpus luteum (CL), adult female rhesus macaques were treated in a model of simulated early pregnancy (SEP). Total RNA was isolated from individual CL after specific intervals of exposure (1, 3, 6 and 9 days) to recombinant hCG in vivo and hybridized to Affymetrix™ GeneChip Rhesus Macaque Genome Arrays. The mRNA levels of 1192 transcripts changed ≥2-fold [one-way ANOVA, false discovery rate (FDR) correction; P< 0.05  ...[more]

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