Genomics

Dataset Information

296

Bifidobacterium breve UCC2003


ABSTRACT: Dominant member of mammalian intestinal microflora

ORGANISM(S): Bifidobacterium breve UCC2003  

PROVIDER: PRJNA13487 | ENA |

REPOSITORIES: ENA

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Publications

Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor.

O'Connell Motherway Mary M   Zomer Aldert A   Leahy Sinead C SC   Reunanen Justus J   Bottacini Francesca F   Claesson Marcus J MJ   O'Brien Frances F   Flynn Kiera K   Casey Patrick G PG   Munoz Jose Antonio Moreno JA   Kearney Breda B   Houston Aileen M AM   O'Mahony Caitlin C   Higgins Des G DG   Shanahan Fergus F   Palva Airi A   de Vos Willem M WM   Fitzgerald Gerald F GF   Ventura Marco M   O'Toole Paul W PW   van Sinderen Douwe D  

Proceedings of the National Academy of Sciences of the United States of America 20110620 27


Development of the human gut microbiota commences at birth, with bifidobacteria being among the first colonizers of the sterile newborn gastrointestinal tract. To date, the genetic basis of Bifidobacterium colonization and persistence remains poorly understood. Transcriptome analysis of the Bifidobacterium breve UCC2003 2.42-Mb genome in a murine colonization model revealed differential expression of a type IVb tight adherence (Tad) pilus-encoding gene cluster designated "tad(2003)." Mutational  ...[more]

Publication: 1/2

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