Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Comparison of hepatic gene expression between short-term calorie restricted wild-type and Dgat1 deficient middle-aged female mice

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA134961 | ENA |

REPOSITORIES: ENA

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Publications


Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Female DGAT1-deficient mice were protected from age-related increases in body fat, tissue triglycerides, and inflammation in white adipose tissue. This protection was accompanied by increased mean and m  ...[more]

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