Genomics

Dataset Information

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Drosophila melanogaster


ABSTRACT: Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila

ORGANISM(S): Drosophila melanogaster  

PROVIDER: PRJNA134997 | ENA |

REPOSITORIES: ENA

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Publications

Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila.

Hartig Julia V JV   Förstemann Klaus K  

Nucleic acids research 20110117 9


In Drosophila, siRNAs are classified as endo- or exo-siRNAs based on their origin. Both are processed from double-stranded RNA precursors by Dcr-2 and then loaded into the Argonaute protein Ago2. While exo-siRNAs serve to defend the cell against viruses, endo-siRNAs restrict the spread of selfish DNA in somatic cells, analogous to piRNAs in the germ line. Endo- and exo-siRNAs display a differential requirement for double-stranded RNA binding domain proteins (dsRBPs): R2D2 is needed to load exo-s  ...[more]

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