Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA135017 | ENA |

REPOSITORIES: ENA

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Publications

Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression.

Hansmann Leo L   Schmidl Christian C   Kett Janina J   Steger Lena L   Andreesen Reinhard R   Hoffmann Petra P   Rehli Michael M   Edinger Matthias M  

Journal of immunology (Baltimore, Md. : 1950) 20111230 3


CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) are pivotal for peripheral self-tolerance. They prevent immune responses to auto- and alloantigens and are thus under close scrutiny as cellular therapeutics for autoimmune diseases and the prevention or treatment of alloresponses after organ or stem cell transplantation. We previously showed that human Treg with a memory cell phenotype, but not those with a naive phenotype, rapidly downregulate expression of the lineage-defining transcription fact  ...[more]

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