Genomics

Dataset Information

0

Mus musculus


ABSTRACT: The roles of ppar-delta and ppar-gamma in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA135035 | ENA |

REPOSITORIES: ENA

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Publications

The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue.

Roberts Lee D LD   Murray Andrew J AJ   Menassa David D   Ashmore Tom T   Nicholls Andrew W AW   Griffin Julian L JL  

Genome biology 20110811 8


The nuclear receptors peroxisome proliferator-activated receptor γ (PPARγ) and peroxisome proliferator-activated receptor δ (PPARδ) play central roles in regulating metabolism in adipose tissue, as well as being targets for the treatment of insulin resistance. While the role of PPARγ in regulating insulin sensitivity has been well defined, research into PPARδ has been limited until recently due to a scarcity of selective PPARδ agonists.The metabolic effects of PPARγ and PPARδ activation have bee  ...[more]

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