Genomics

Dataset Information

0

Mus musculus


ABSTRACT: S100A8/A9 activate key genes and pathways in colon tumor progression

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA135039 | ENA |

REPOSITORIES: ENA

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Publications

S100A8/A9 activate key genes and pathways in colon tumor progression.

Ichikawa Mie M   Williams Roy R   Wang Ling L   Vogl Thomas T   Srikrishna Geetha G  

Molecular cancer research : MCR 20110112 2


The tumor microenvironment plays an important role in modulating tumor progression. Earlier, we showed that S100A8/A9 proteins secreted by myeloid-derived suppressor cells (MDSC) present within tumors and metastatic sites promote an autocrine pathway for accumulation of MDSC. In a mouse model of colitis-associated colon cancer, we also showed that S100A8/A9-positive cells accumulate in all regions of dysplasia and adenoma. Here we present evidence that S100A8/A9 interact with RAGE and carboxylat  ...[more]

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