Dataset Information


Mus musculus

ABSTRACT: Expression data from control and Phospholipid dependent kinase 1 (PDK1) null cytotoxic T-lymphocytes (CTL) and from control and Akt inhibitor treated CTL

ORGANISM(S): Mus musculus  



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Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.

Macintyre Andrew N AN   Finlay David D   Preston Gavin G   Sinclair Linda V LV   Waugh Caryll M CM   Tamas Peter P   Feijoo Carmen C   Okkenhaug Klaus K   Cantrell Doreen A DA  

Immunity 20110203 2

In cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 (IL-2). Akt can control cell metabolism in many cell types but whether this role is important for CTL function has not been determined. Here we have shown that Akt does not mediate IL-2- or TCR-induced cell metabolic responses; rather, this role is assumed by other Akt-related kinases. There is, however, a nonredundant role for sustained and strong act  ...[more]

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