Dataset Information


Homo sapiens

ABSTRACT: Genome-wide analysis of lung myeloid dendritic cells gene expression from healthy or emphysema subjects

ORGANISM(S): Homo sapiens  



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Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema.

Shan Ming M   Yuan Xiaoyi X   Song Li-Zhen LZ   Roberts Luz L   Zarinkamar Nazanin N   Seryshev Alexander A   Zhang Yiqun Y   Hilsenbeck Susan S   Chang Seon-Hee SH   Dong Chen C   Corry David B DB   Kheradmand Farrah F  

Science translational medicine 20120101 117

Smoking-related lung diseases are among the leading causes of death worldwide, underscoring the need to understand their pathogenesis and develop new effective therapies. We have shown that CD1a+ antigen-presenting cells (APCs) from lungs of patients with emphysema can induce autoreactive T helper 1 (T(H)1) and T(H)17 cells. Similarly, the canonical cytokines interferon-γ (IFN-γ) and interleukin-17A (IL-17A) are specifically linked to lung destruction in smokers, but how smoke activates APCs to  ...[more]

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