Dataset Information


Streptococcus pneumoniae D39

ABSTRACT: cps wild type vs cps mgtA mutant

ORGANISM(S): Streptococcus pneumoniae D39  



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Deletion of a cation transporter promotes lysis in Streptococcus pneumoniae.

Neef Jolanda J   Andisi Vahid Farshchi VF   Kim Kwang S KS   Kuipers Oscar P OP   Bijlsma Jetta J E JJ  

Infection and immunity 20110321 6

Streptococcus pneumoniae is a significant human pathogen which causes respiratory and serious invasive diseases. Mg(2+) is essential for life, and its concentration varies throughout the human body. Magnesium uptake plays an important role in the virulence of many bacterial pathogens. To study the Mg(2+) uptake of S. pneumoniae strain D39, a mutant was generated in SPD1383, a P-type ATPase with homology to the Salmonella Mg(2+) transporter MgtA, which has also been shown to be a Ca(2+) exporter  ...[more]

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